CPP & CQA in Capsule Manufacturing

CRITICAL PROCESS PARAMETERS AND CRITICAL QUALITY ATTRIBUTES AND CRITICAL PROCESS PARAMETERS IN CAPSULE MANUFACTURING

Stage: Blending/Mixing 

CPP

• Order of addition
• Blender oad level
• Blending time
• Blending speed

CQA

• Bulk/tapped density
• Moisture content
• Flow properties

Stage: Capsule Filling

CPP

• Cone design, height and vibration
• Auger filler rotation
• Rotating tray speed

CQA

• Uniformity of weight
• Tapping and locking
• Closed length
• Disintegration time

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