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CEP vs ASMF – Which API Route Works Best for EU Submissions?

 


CEP:

  • CEP = Certificate of Suitability
  • Issued by EDQM
  • Confirm API complies with European Pharmacopoea
  • Widely accepted across EU/ EEA
  • Faster review process

ASMF:
  • ASMF = Active Substance Master File
  • Submitted to EU authorities via MAA
  • API data splited into - open part and restricted part
  • Used when CEP not available
  • Longer review process

CEP is the preferred and more efficient route for EU API submissions whenever available, while ASMF serves as an alternative when CEP is not feasible.

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