An Introduction to Medicinal Chemistry is the leading textbook for university courses on this subject. Due to more informative contents this book is loved equally by both students and lecturers, it presents complete coverage in an accessible and engaging style.
Table of Contents of An Introduction to Medicinal Chemistry
1. Drugs and drug targets - an overview
Part A: Drug targets - structure and function
2. Protein structure and function
3. Enzymes: structure and function
4. Receptors: structure and function
5. Receptors and signal transduction
6. Nucleic acids: structure and function
Part B: Pharmacodynamics and pharmacokinetics
7. Enzymes as drug targets
8. Receptors as drug targets
9. Nucleic acids as drug targets
10. Miscellaneous drug targets
11. Pharmacokinetics and related topics
Case study 1: Statins
Part C: Drug discovery, design, and development
12. Drug discovery: finding a lead
13. Drug design: optimizing target interactions
14. Drug design: optimizing access to the target
15. Getting the drug to market
Case study 2: The design of ACE inhibitors
Case study 3: Artemisinin and related antimalarial drugs
Case study 4: The design of oxamniquine
Part D: Tools of the trade
16. Combinatorial synthesis
17. Computers in medicinal chemistry
18. Quantitative structure-activity relationships (QSAR)
Case study 5: De novo design of a thymidylate synthase inhibitor
Part E: Selected topics in medicinal chemistry
19. Antibacterial agents
20. Antiviral agents
21. Anticancer agents
22. Cholinergics, anticholinergics, and anticholinesterases
23. Drugs acting on the adrenergic nervous system
24. Opioid analgesics
25. Antiulcer agents
26. Cardiovascular drugs
Case study 6: Steroidal anti-inflammatory agents
Case Study 7: Design of a novel antidepressant
Case Study 8: The design and development of aliskiren
Case Study 9: Factor Xa inhibitors
Case Study 10: Reversible inhibitors of HCV NS3-4A protease
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