Author: Graham Patrick
Edition: 5th
Originally published: 1995

An Introduction to Medicinal Chemistry is the leading textbook for university courses on this subject. Due to more informative contents this book is loved equally by both students and lecturers, it presents complete coverage in an accessible and engaging style.


Table of Contents of An Introduction to Medicinal Chemistry

1. Drugs and drug targets - an overview

Part A: Drug targets - structure and function

2. Protein structure and function

3. Enzymes: structure and function

4. Receptors: structure and function

5. Receptors and signal transduction

6. Nucleic acids: structure and function

Part B: Pharmacodynamics and pharmacokinetics

7. Enzymes as drug targets

8. Receptors as drug targets

9. Nucleic acids as drug targets

10. Miscellaneous drug targets

11. Pharmacokinetics and related topics

Case study 1: Statins

Part C: Drug discovery, design, and development

12. Drug discovery: finding a lead

13. Drug design: optimizing target interactions

14. Drug design: optimizing access to the target

15. Getting the drug to market

Case study 2: The design of ACE inhibitors

Case study 3: Artemisinin and related antimalarial drugs

Case study 4: The design of oxamniquine

Part D: Tools of the trade

16. Combinatorial synthesis

17. Computers in medicinal chemistry

18. Quantitative structure-activity relationships (QSAR)

Case study 5: De novo design of a thymidylate synthase inhibitor

Part E: Selected topics in medicinal chemistry

19. Antibacterial agents

20. Antiviral agents

21. Anticancer agents

22. Cholinergics, anticholinergics, and anticholinesterases

23. Drugs acting on the adrenergic nervous system

24. Opioid analgesics

25. Antiulcer agents

26. Cardiovascular drugs

Case study 6: Steroidal anti-inflammatory agents

Case Study 7: Design of a novel antidepressant

Case Study 8: The design and development of aliskiren

Case Study 9: Factor Xa inhibitors

Case Study 10: Reversible inhibitors of HCV NS3-4A protease



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