Drug release kinetics is the science of how a drug leaves its dosage form and becomes available for absorption. It plays a critical role in ensuring therapeutic efficacy, safety, and patient compliance.
Key Kinetic Models in Drug Release:
Zero Order
- Constant release over time (ideal for controlled release).
First Order
- Release depends on drug concentration (common for soluble drugs).
Higuchi Model
- Diffusion-based release from matrices.
Hixson–Crowell Model
- Release governed by changing surface area & particle size.
Korsmeyer Peppas Model
- Explains complex mechanisms (diffusion, erosion, or both).
Why it matters:
- Predicts in vivo performance from in vitro dissolution data
- Supports IVIVC development
- Ensures robust product design and regulatory acceptance
In formulation R&D, mastering release kinetics is more than theory—it’s the foundation of designing immediate, sustained, and controlled release medicines.
Read also: Intrinsic Dissolution Rate
Resource Person: Vijay Agrawal
