Understanding the differences between fasting and fed conditions is essential for predicting drug behavior in the gastrointestinal (GI) tract.
These conditions significantly affect factors such as pH, transit time, fluid volume, viscosity, and osmolarity in various GI regions. Such physiological changes can influence drug dissolution, absorption, and overall bioavailability, making this knowledge crucial for designing successful in vitro and bioequivalence (BE) studies.
Read also: Fasting vs. Fed Dosing and the Role of Dissolution Media