Good chromatography ends with great data but great science begins with clear, traceable reporting. Here’s how your CDS (Chromatography data system) helps make it happen.
The report is where your science is recorded, reviewed, and repeated.
But what exactly is a chromatography report and why does it matter so much?
Let’s break it down.
A chromatography report is the output generated from a Chromatography Data System (CDS) like Empower, LabSolutions, Chromeleon, or OpenLab.
It contains the data, context, and calculations that turns raw signals into scientific conclusions.
What Should a Strong Report Include?
1. Sample & system data
Sample name, injection volume, method, batch info, system info.
2. Chromatogram
A visual plot of detector response vs. retention time.
3. Peak Table
Including retention times, areas, heights, and % composition.
4. Calibration Curve
Standards, concentration vs. response, and regression data.
5. System Suitability Test (SST)
Key metrics like resolution, tailing factor, theoretical plates.
6. Instrument and processing Method
The instrument method is used to acquire data while the processing method defines how peaks were integrated and quantified. (in some softwares there is only one method)
7. Audit Trail
Ensures traceability, critical in regulated environments or quality control.
8. Electronic Signatures
For approval workflows and data integrity compliance.
Common Report Mistakes to Avoid
Even experienced analysts can fall into these common issues including:
- Chromatogram not fully displayed.
- Outdated or incorrect calibration curve applied
- Method version not documented which affects traceability.
- Missing record of who processed or approved the data. (No Audit trail)
- System suitability test data is not shown or not calculated.
- Poor file naming or organization.
Pro Tips
Build report templates for different workflows (R&D report, QC report, Stability report)
Standardized, pre-validated templates:
- Saves time
- Reduces errors
- Ensures compliance
- Improves review efficiency
Always include versioned methods and system details.
Don’t forget data backup and archiving.
In chromatography, you don’t just generate data you generate trust. And trust starts with the analyst and ends with the report.
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Resource Person: Abanoub Efraim
