Pharmacy Courses

Basics of Scale-Up Techniques in Pharmaceutical Industry

According to the modeling theory, two processes may be considered similar if there is a:

GEOMETRICAL SIMILARITY

Two systems are called geometrically similar if they have the same ratio of characteristic linear dimensions. For example, two cylindrical mixing vessels are geometrically similar if they have the same ratio of height to diameter.


KINEMATIC SIMILARITY

Two geometrically similar systems are called kinematically similar if they have the same ratio of velocities between corresponding system points.


DYNAMIC SIMILARITY

Two kinematically similar systems are dynamically similar when they have the same ratio of forces between corresponding points. Dynamic similitude for wet granulation would imply that the wet mass flow patterns in the bowl are similar.


Scale-Up Models for All Unit Operations


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